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Histamine Intolerance: A Gut–Vagus–Mast Cell Story

Histamine intolerance is rarely "just" a DAO enzyme problem. It sits at the intersection of gut microbiome health, mast cell reactivity, and vagal regulation — and the most durable treatments address all three.

By VagusSkool Team May 11, 2026

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MCAS and the Vagal Brake: Why Mast Cells Need a Quiet Nervous System

Mast cells are wired into the autonomic nervous system. When the vagal brake fails, mast cells become reactive — and the cholinergic anti-inflammatory pathway emerges as one of the most underused tools in MCAS care.

By VagusSkool Team May 11, 2026